Toward clinically relevant automated corneal biomanufacturing with human-derived FBS alternatives
Alexandre Taoum, Julia S. Oster, Ole Thaden, Andrea Frank, Meng Wang, Mario Wisbar, Matthias Fuest, Friederike Dehli, Daniela F. Duarte Campos · 2026
Read Toward clinically relevant automated corneal biomanufacturing with human-derived FBS alternatives by Alexandre Taoum, Julia S. Oster, Ole Thaden, Andrea Frank, Meng Wang, Mario Wisbar, Matthias Fuest, Friederike Dehli, Daniela F. Duarte Campos (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276165.txt.
Description
Alexandre Taoum and co-authors report a 2026 journal article on growing cornea cells without animal products. Labs usually feed cells with fetal bovine serum, taken from calves, which varies between batches and complicates approval for human use. The team tested two human-derived options for eye tissue engineering.
Bone marrow stem cells were eased onto low doses of platelet lysate or human serum, then switched to a serum-free medium that turns them toward cornea-like cells. Both human options kept cells active and supported the right marker proteins as well as calf serum did. Cells also behaved in jelly-like three-dimensional gels lit by blue light. The authors say these swaps support automated, clinic-ready production of corneal tissue with far fewer animal ingredients.
Catalog record
| CREATOR | Alexandre Taoum, Julia S. Oster, Ole Thaden, Andrea Frank, Meng Wang, Mario Wisbar, Matthias Fuest, Friederike Dehli, Daniela F. Duarte Campos |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50882 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |