Glucosamine/chitosan blend surface-engineered rutin-loaded polymer/lipid hybrid nanoparticles for neuroprotection in induced schizophrenia model
Abeer Salama, Rania Elgohary, Alaa H. Salama, Heba Elmotasem · 2026
Read Glucosamine/chitosan blend surface-engineered rutin-loaded polymer/lipid hybrid nanoparticles for neuroprotection in induced schizophrenia model by Abeer Salama, Rania Elgohary, Alaa H. Salama, Heba Elmotasem (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276060.txt.
Description
Abeer Salama and co-authors report a 2026 journal article on a new drug carrier meant to protect the brain. The cargo is rutin, a plant compound that may shield nerve cells but dissolves poorly in water. The team packed it into hybrid nanoparticles, tiny spheres part polymer and part lipid, meaning fat-like material.
One formula loaded the drug well and stayed small. Coating it with a glucosamine and chitosan blend, both sugar-based materials, changed how fast rutin leaked out. In mice with a chemically induced schizophrenia-like condition, the coated carrier worked better than both plain rutin and the uncoated carrier. Treated mice showed restored levels of two brain proteins tied to myelin, the insulation around nerve fibers. Chemical balance in the brain also steadied.
Catalog record
| CREATOR | Abeer Salama, Rania Elgohary, Alaa H. Salama, Heba Elmotasem |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61014 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |