Genetically engineered probiotic E. coli Nissle 1917 enhances protection against Salmonella via increased adhesion and systemic T-cell responses
Ewa Carolak, Joanna Czajkowska, Wiktoria Waszczuk, Agata Dutkiewicz, Anna Ewa Kedzierska, Krzysztof Grzymajlo · 2026
Read Genetically engineered probiotic E. coli Nissle 1917 enhances protection against Salmonella via increased adhesion and systemic T-cell responses by Ewa Carolak, Joanna Czajkowska, Wiktoria Waszczuk, Agata Dutkiewicz, Anna Ewa Kedzierska, Krzysztof Grzymajlo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13275912.txt.
Description
Ewa Carolak and co-authors tuned a probiotic germ in 2026 so it guards mice better against Salmonella. The probiotic, Escherichia coli Nissle 1917, is a friendly gut strain, but how it protects was unclear. One small change to its grip protein made it cling far more tightly. The tuned strain blocked Salmonella from latching on and nudged the host toward adaptive immune talk rather than raw fire signals.
Mice dosed ahead shed less Salmonella, held less in the gut and body, and kept normal spleens. Both helper and killer T cells swelled, and the spleen stayed primed even with no infection. No harm to the host showed. The team pitches the tuned strain as a two-way guard and a base for microbe drugs.
Catalog record
| CREATOR | Ewa Carolak, Joanna Czajkowska, Wiktoria Waszczuk, Agata Dutkiewicz, Anna Ewa Kedzierska, Krzysztof Grzymajlo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |