Lipidomic predictors of residual insulin production in adults with newly diagnosed type 1 diabetes
Pernille Emilie Hostrup, Karolina Sulek, Flemming Pociot · 2026
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Description
Pernille Emilie Hostrup and co-authors present a 2026 journal article on type 1 diabetes in adults. In this disease the immune system destroys the cells that make insulin, the hormone that controls blood sugar. Some patients keep making a little insulin after diagnosis, and predicting who will matters for trials.
The team profiled lipids, the fats in blood plasma, from twenty-nine newly diagnosed adults. They tested which fats predicted later insulin output, measured through a marker called C-peptide after a test meal. One fat family, shortened to LPCs, stood out as the strongest predictor. Higher levels at diagnosis meant more insulin still being made a year later. Lower levels of another fat group, sphingolipids, pointed the other way. The pattern differed from earlier work in children.
Catalog record
| CREATOR | Pernille Emilie Hostrup, Karolina Sulek, Flemming Pociot |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44033 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |