Integrative analysis of hub genes for recurrent pregnancy loss with antiphospholipid syndrome: integrated bioinformatics analysis, machine learning and experimental validation
Huan Zeng, Chengming Ding, Weilei Dong, Haochuan Long, Zhen Liu, Yulu Guo, Yuji Xiao, Wenyan Liao · 2026
Read Integrative analysis of hub genes for recurrent pregnancy loss with antiphospholipid syndrome: integrated bioinformatics analysis, machine learning and experimental validation by Huan Zeng, Chengming Ding, Weilei Dong, Haochuan Long, Zhen Liu, Yulu Guo, Yuji Xiao, Wenyan Liao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13275653.txt.
Description
Huan Zeng and colleagues present a 2026 gene analysis of repeated pregnancy loss linked with antiphospholipid syndrome. In that syndrome, the immune system produces antibodies that raise clotting and pregnancy risks. The shared biology behind both conditions remains unclear, which limits diagnosis and care.
Public gene datasets for both conditions were compared, and ten shared altered genes emerged. Machine learning narrowed the list to three hub genes: NAA30, ARHGAP44, and SUGT1. A prediction model built on these genes was checked with standard accuracy curves. Follow-up cell tests supported the findings, and immune imbalance appeared as a common thread across both conditions.
Catalog record
| CREATOR | Huan Zeng, Chengming Ding, Weilei Dong, Haochuan Long, Zhen Liu, Yulu Guo, Yuji Xiao, Wenyan Liao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |