Multi-omics analysis positions DNA2 at the interface of genome integrity programs and tumor behavior in pan-cancer
Depanshi Pandit, Amardeep Dhillon, Sanjiban Chakrabarty, Ravindranath Sanganabasappa Bilachi · 2026
Read Multi-omics analysis positions DNA2 at the interface of genome integrity programs and tumor behavior in pan-cancer by Depanshi Pandit, Amardeep Dhillon, Sanjiban Chakrabarty, Ravindranath Sanganabasappa Bilachi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13275593.txt.
Description
Depanshi Pandit and colleagues present a 2026 journal article profiling the DNA maintenance protein DNA2 across all major cancers. DNA2 helps cells copy and repair DNA, and overactive repair can help tumors survive stress. Using national cancer genome cohorts and other public databases, the team ran the first pan-cancer multi-omics study of this gene, spanning expression, mutations, survival, and immune patterns.
DNA2 was overexpressed in seventeen tumor types compared with normal tissue, and endometrial cancer showed the most frequent genetic changes, about seven percent. High DNA2 tracked with worse survival in several cancers, most sharply in adrenocortical carcinoma. It also tracked with more regulatory immune cells and fewer killer cells. Two drugs, tozasertib and daporinad, hit high-DNA2 tumor cells harder in drug-response data.
Catalog record
| CREATOR | Depanshi Pandit, Amardeep Dhillon, Sanjiban Chakrabarty, Ravindranath Sanganabasappa Bilachi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68976 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |