Distinct repair outcomes from single and convergent replication fork collapse
Sara C. Conwell, Khushi V. N. Patel, Savannah J. Weeks-Pollenz, Steven N. Dahmen, Matthew T. Cranford, William G. Dunphy, David T. Long, David Cortez, James M. Dewar · 2026
Read Distinct repair outcomes from single and convergent replication fork collapse by Sara C. Conwell, Khushi V. N. Patel, Savannah J. Weeks-Pollenz, Steven N. Dahmen, Matthew T. Cranford, William G. Dunphy, David T. Long, David Cortez, James M. Dewar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13275508.txt.
Description
Sara C Conwell and co-authors report a 2026 study of how cells repair collapsed DNA replication forks. When a moving fork hits a single-strand break, the DNA can snap and stall copying. The repair route matters because failed repair can drive mutations and cancer.
The team recreated precise DNA nicks in frog egg extracts, using one fork or two converging forks. A single collapsed fork formed a one-ended break repaired by recombination, without restarting copying. Two forks collapsing together formed a two-ended break repaired by an annealing route that finished copying. That second route produced small deletions and insertions, showing how fork geometry shapes repair accuracy.
Catalog record
| CREATOR | Sara C. Conwell, Khushi V. N. Patel, Savannah J. Weeks-Pollenz, Steven N. Dahmen, Matthew T. Cranford, William G. Dunphy, David T. Long, David Cortez, James M. Dewar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 99 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |