Recombinant human IGF-1 alleviates dyslipidemia induced by lactational maternal dietary restriction
Xin Liu, Yuanyuan Ma, Hong Cui, Qi Feng · 2026
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Description
Xin Liu and colleagues report a 2026 rat study of poor early growth after mothers ate a restricted diet during nursing. Such growth restriction affects preterm infants and can disturb blood fats and sugars. The team tested whether a growth factor treatment, recombinant human IGF-1, could correct the problem.
Pups from restricted mothers weighed less and were shorter at three weeks, with altered cholesterol and triglyceride patterns. The growth factor did not restore growth, although it lowered one cholesterol measure. Gene activity in the liver pointed to lipoprotein lipase, a fat-processing enzyme. Raising that enzyme in human liver cells lowered two fat-making genes, suggesting a pathway behind the changes.
Catalog record
| CREATOR | Xin Liu, Yuanyuan Ma, Hong Cui, Qi Feng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |