Machine learning–guided multimodal profiling defines perturbed immune states at the time of cancer diagnosis
Peggy Berlin, Amin Mirzaei, Felix Steinbeck, Martin Becker, Brigitte Müller-Hilke, Wendy Bergmann-Ewert, Daniel Dubinski, Thomas M Freiman, Daniel Strüder, Theresa Momper, Annabell Wolff, Philipp Kaps, Julia Henne, Clemens Schafmayer, Michael Linnebacher, Charlotte Wagner, Karen Rischmüller, Martin · 2026
Read Machine learning–guided multimodal profiling defines perturbed immune states at the time of cancer diagnosis by Peggy Berlin, Amin Mirzaei, Felix Steinbeck, Martin Becker, Brigitte Müller-Hilke, Wendy Bergmann-Ewert, Daniel Dubinski, Thomas M Freiman, Daniel Strüder, Theresa Momper, Annabell Wolff, Philipp Kaps, Julia Henne, Clemens Schafmayer, Michael Linnebacher, Charlotte Wagner, Karen Rischmüller, Martin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13274990.txt.
Description
Peggy Berlin and a large team profiled the immune state of patients at the moment of cancer diagnosis in a 2026 study. Blood immune markers could reveal how tumors reshape the body before any treatment confounds the picture. The team combined cell sorting counts, cytokine measures, and single cell gene reads from untreated patients and healthy donors. Machine learning models then integrated the layers.
Patients showed wide immune disturbance: more regulatory T cells, fewer of certain monocyte and natural killer cell types, and raised levels of two signaling proteins. Single cell data found cancer linked gene signatures switched on across cells, as if the tumor imprinted the whole system. The models classified patients robustly within the cohort and flagged which features drove the calls. The authors frame diagnosis time immune profiling as an underused window.
Catalog record
| CREATOR | Peggy Berlin, Amin Mirzaei, Felix Steinbeck, Martin Becker, Brigitte Müller-Hilke, Wendy Bergmann-Ewert, Daniel Dubinski, Thomas M Freiman, Daniel Strüder, Theresa Momper, Annabell Wolff, Philipp Kaps, Julia Henne, Clemens Schafmayer, Michael Linnebacher, Charlotte Wagner, Karen Rischmüller, Martin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |