A chemical bactericide dioctyldiethylenetriamine (Xinjunan) exerts a non-lethal effect by inhibiting RpfG activity to regulate the quorum sensing system
Ling Jin, Xing Chen, Chaoyue Pang, Yongquan Huang, Changshun Ji, Yuanyuan Zhang, Xueqiao Liu, Yang Sun, Yu Chen · 2026
Read A chemical bactericide dioctyldiethylenetriamine (Xinjunan) exerts a non-lethal effect by inhibiting RpfG activity to regulate the quorum sensing system by Ling Jin, Xing Chen, Chaoyue Pang, Yongquan Huang, Changshun Ji, Yuanyuan Zhang, Xueqiao Liu, Yang Sun, Yu Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13274925.txt.
Description
Ling Jin and colleagues present a 2026 journal article on a farm bactericide that also disarms bacteria without killing them. Killing sprays breed resistance, so weakening germs is an attractive extra weapon. The chemical, dioctyldiethylenetriamine, was tested on the rice blight bacterium Xanthomonas oryzae, and a gene-hunt pointed at its quorum sensing system, the chatter bacteria use to coordinate attacks.
The drug suppressed RpfG, the protein that relays those signals, at both gene and protein levels. With its signal enzyme crippled, the bacteria lost coordination, a state called quorum quenching. Their virulence and swimming both dropped, so fewer escaped the spray's direct killing. The quenching appeared only in bacteria carrying RpfG, a specificity the authors value.
Catalog record
| CREATOR | Ling Jin, Xing Chen, Chaoyue Pang, Yongquan Huang, Changshun Ji, Yuanyuan Zhang, Xueqiao Liu, Yang Sun, Yu Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98933 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |