Spatial transcriptome mapping identifies Ppara-Anxa2 cross-talk in microplastic-induced hepatotoxicity
Woncheol Jung, Hassan Abushukair, Nikhil Y. Patil, Felix Ampadu, Maryam Firouzi, Iulia Rus, Jinhyuk Choi, Sree Deepthi Muthukrishnan, Surendra Shukla, Stefano Tarantini, Anna Csiszar, Kamiya Mehla, Dongin Kim, Je-Hyun Yoon, Dowoon Kim, Juyang Kim, Jaehak Jung, Oxana Klementieva, Yatrik M. Shah, Eiji Yoshihara, Pankaj K. Singh, Aditya D. Joshi, Tae Gyu Oh · 2026
Read Spatial transcriptome mapping identifies Ppara-Anxa2 cross-talk in microplastic-induced hepatotoxicity by Woncheol Jung, Hassan Abushukair, Nikhil Y. Patil, Felix Ampadu, Maryam Firouzi, Iulia Rus, Jinhyuk Choi, Sree Deepthi Muthukrishnan, Surendra Shukla, Stefano Tarantini, Anna Csiszar, Kamiya Mehla, Dongin Kim, Je-Hyun Yoon, Dowoon Kim, Juyang Kim, Jaehak Jung, Oxana Klementieva, Yatrik M. Shah, Eiji Yoshihara, Pankaj K. Singh, Aditya D. Joshi, Tae Gyu Oh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13274612.txt.
Description
Woncheol Jung and a large team present a 2026 journal article mapping how microplastic exposure injures mouse livers, neighborhood by neighborhood. Polyethylene is the commonest plastic, yet its liver effects were poorly defined. The team fed mice standard or fatty-liver-inducing diets with the plastic and combined standard gene profiling with spatial transcriptomics, which keeps location in the tissue.
Exposure caused liver dysfunction on both diets, with gene changes spread unevenly across the organ. Spatial maps revealed inflammatory hotspots where cell variety shrank. One control switch, the nuclear receptor Ppara, stood out as a modulator. The team showed it directly regulates Anxa2, a gene for damage response and tissue recovery, suggesting targets for intervention.
Catalog record
| CREATOR | Woncheol Jung, Hassan Abushukair, Nikhil Y. Patil, Felix Ampadu, Maryam Firouzi, Iulia Rus, Jinhyuk Choi, Sree Deepthi Muthukrishnan, Surendra Shukla, Stefano Tarantini, Anna Csiszar, Kamiya Mehla, Dongin Kim, Je-Hyun Yoon, Dowoon Kim, Juyang Kim, Jaehak Jung, Oxana Klementieva, Yatrik M. Shah, Eiji Yoshihara, Pankaj K. Singh, Aditya D. Joshi, Tae Gyu Oh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72696 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |