Life-span–dependent transcriptional dynamics of the human heart
Hao Jia, Xiao Chen, Yuan Chang, Yifan Wang, Eric L. Lindberg, Hao Cui, Yihang Feng, Ningning Zhang, Xiulin Zhang, Mengda Xu, Dan Shan, Yixuan Sheng, Fengxiang Wei, Xiumeng Hua, Han Mo, Yuhong Hu, Xijia Shao, Han Han, Daniel Reichart, Jiangping Song · 2026
Read Life-span–dependent transcriptional dynamics of the human heart by Hao Jia, Xiao Chen, Yuan Chang, Yifan Wang, Eric L. Lindberg, Hao Cui, Yihang Feng, Ningning Zhang, Xiulin Zhang, Mengda Xu, Dan Shan, Yixuan Sheng, Fengxiang Wei, Xiumeng Hua, Han Mo, Yuhong Hu, Xijia Shao, Han Han, Daniel Reichart, Jiangping Song (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13274588.txt.
Description
Hao Jia and a large team report a 2026 journal article mapping how gene activity in the human heart changes across the whole life span. They built an atlas from single-nucleus RNA sequencing of nonfailing heart tissue. The data cover 442,239 cell nuclei from fifty-four samples donated by twenty-nine people, from development through old age.
Across all major cell types, aging brought a progressive loss of orderly gene control plus rising stress and inflammation signals. Heart muscle cells showed distinct aged states rich in senescence markers. One regulator, PRDM16, faded with age; disturbing it aged lab-grown heart cells, while restoring balance in old mouse hearts improved function. Their age-prediction models tracked real age and flagged faster aging in diseased hearts.
Catalog record
| CREATOR | Hao Jia, Xiao Chen, Yuan Chang, Yifan Wang, Eric L. Lindberg, Hao Cui, Yihang Feng, Ningning Zhang, Xiulin Zhang, Mengda Xu, Dan Shan, Yixuan Sheng, Fengxiang Wei, Xiumeng Hua, Han Mo, Yuhong Hu, Xijia Shao, Han Han, Daniel Reichart, Jiangping Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83323 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |