Programming Nonlinear Interfacial Mechanics of Synthetic Cells: Lipid Geometry and DNA Nanostructures
Kazutoshi Masuda, Miho Yanagisawa · 2026
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Description
Kazutoshi Masuda and Miho Yanagisawa present a 2026 journal article on programming the squishiness of synthetic cells. Artificial cells wrapped in fat membranes are used to mimic life and carry drugs, but predicting how their skins bend and stretch was hard. The team built a math framework tested by sucking the coated droplets into a tiny pipette.
Their model fits the full pressure response using just two numbers: one for skin stretching and one for bending. Changing the shape of the fat molecules tuned the stretching stiffness. Adding DNA nanostructures gave a separate control knob, and three-dimensional DNA networks sharply raised bending resistance. The pair of knobs offers a design rule for tunable artificial cells.
Catalog record
| CREATOR | Kazutoshi Masuda, Miho Yanagisawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49271 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |