Quercetin ameliorates aflatoxin B1-induced non-canonical ferroptosis in ovine oocytes through the OPA1/ACSL4 pathway
Lang Li, Bin Liu, Zhenzhen Wang, Ruiwen Zhao, Xiong Xiao, Yongju Zhao, Xiaoyan Qiu · 2026
Read Quercetin ameliorates aflatoxin B1-induced non-canonical ferroptosis in ovine oocytes through the OPA1/ACSL4 pathway by Lang Li, Bin Liu, Zhenzhen Wang, Ruiwen Zhao, Xiong Xiao, Yongju Zhao, Xiaoyan Qiu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13274008.txt.
Description
Lang Li and co-authors present a 2026 journal article on a mold toxin that harms sheep egg cells. Aflatoxin B1 grows in feeds such as maize and soy and can damage animal reproduction. The team studied sheep oocytes, the egg cells, and tested whether quercetin, a plant compound, could protect them.
Using protein screening and follow-up tests, the team singled out two proteins, OPA1 and ACSL4. The toxin raised both, wrecked the cells' energy-making structures, and drove an iron-linked form of cell death called ferroptosis. Quercetin bound both proteins more strongly than the toxin did. Adding it eased the abnormal protein changes and the damage that followed in the egg cells.
Catalog record
| CREATOR | Lang Li, Bin Liu, Zhenzhen Wang, Ruiwen Zhao, Xiong Xiao, Yongju Zhao, Xiaoyan Qiu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81574 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |