BTKi orelabrutinib improved the outcome of newly-diagnosed PCNS-LBCL by alleviating MyD88L265P-induced PIM1 stability
Yan Yuan, Bo Dai, Haoshu Zhong, Jiajun Zheng, Zhen Fan, Di Chen, Qian Wang, Hao Wu, Yuan Li, Ping Zhu, Tianling Ding, Shu Wang, Kunpeng Wu, Yu Zhang, Zhenhua Wang, Rui Feng, Fengping Zhu, Kang Zheng, Zhiyong Qin, Bojie Yang, Hong Chen, Xiaolei Lin, Yu Yao, Dongxiao Zhuang, Zhifeng Shi, Ying Mao, Tong Chen · 2026
Read BTKi orelabrutinib improved the outcome of newly-diagnosed PCNS-LBCL by alleviating MyD88L265P-induced PIM1 stability by Yan Yuan, Bo Dai, Haoshu Zhong, Jiajun Zheng, Zhen Fan, Di Chen, Qian Wang, Hao Wu, Yuan Li, Ping Zhu, Tianling Ding, Shu Wang, Kunpeng Wu, Yu Zhang, Zhenhua Wang, Rui Feng, Fengping Zhu, Kang Zheng, Zhiyong Qin, Bojie Yang, Hong Chen, Xiaolei Lin, Yu Yao, Dongxiao Zhuang, Zhifeng Shi, Ying Mao, Tong Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13273950.txt.
Description
Yan Yuan and a large team report a 2026 journal article on a targeted drug for a rare brain lymphoma. The cancer, primary central nervous system large B-cell lymphoma, has the worst outlook of its lymphoma group. Many tumors carry a change in the MyD88 gene that helps cancer cells survive.
The team showed that this gene change raises levels of a protein called BTK, which in turn protects another cancer protein, PIM1. In mouse models, the drug orelabrutinib crossed into the brain, blocked BTK, and helped break down PIM1. Patients given orelabrutinib with methotrexate responded better and lived longer than a comparison group. Tumor DNA in spinal fluid matched tumor tissue better than DNA in blood.
Catalog record
| CREATOR | Yan Yuan, Bo Dai, Haoshu Zhong, Jiajun Zheng, Zhen Fan, Di Chen, Qian Wang, Hao Wu, Yuan Li, Ping Zhu, Tianling Ding, Shu Wang, Kunpeng Wu, Yu Zhang, Zhenhua Wang, Rui Feng, Fengping Zhu, Kang Zheng, Zhiyong Qin, Bojie Yang, Hong Chen, Xiaolei Lin, Yu Yao, Dongxiao Zhuang, Zhifeng Shi, Ying Mao, Tong Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20115 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |