A multistage micro-nano biosystem prevents sepsis-associated encephalopathy through coordinated neuroinflammation suppression and gut-brain axis modulation
Xuening Zhang, Jia Dong, Wentao Liu, Shiyuan Hua, Donghu Lin, Jiahua Niu, Min Zhou · 2026
Read A multistage micro-nano biosystem prevents sepsis-associated encephalopathy through coordinated neuroinflammation suppression and gut-brain axis modulation by Xuening Zhang, Jia Dong, Wentao Liu, Shiyuan Hua, Donghu Lin, Jiahua Niu, Min Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13273896.txt.
Description
Zhang and colleagues build a system from algae and nanoparticles to prevent sepsis-associated encephalopathy. Their 2026 journal article combines Chlorella algae with liposomes loaded with melatonin. The condition is brain dysfunction triggered by severe infection.
The system is named CV@MT-NPs. The algae carry the particles through the body. This extended how long melatonin stayed in circulation. More of the drug also reached and stayed in the brain. In mice with LPS-induced disease, survival improved. Thinking deficits and anxiety-like behaviors eased. The particles protected the blood-brain barrier. They restored tight junction proteins and calmed microglia. The gut barrier and gut microbes also improved. Short-chain fatty acids rose in both gut and brain. Safety tests showed no acute or chronic toxicity.
Catalog record
| CREATOR | Xuening Zhang, Jia Dong, Wentao Liu, Shiyuan Hua, Donghu Lin, Jiahua Niu, Min Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77358 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |