Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang · 2026
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Description
An and colleagues review ischemia-reperfusion injury, the damage that can follow when blood flow returns to starved tissue. Their 2026 review article spans the heart, transplant organs, and shock care. The paradox is that restored flow can worsen injury.
The review traces the injury cascade step by step. During ischemia, cells lose energy and ion balance fails. Reperfusion then harms mitochondria and sparks oxidative stress. Cell death programs switch on. Inflammation recruits neutrophil extracellular traps, called NETs. These webs link vessel blockage with immune signaling. They can spread damage to distant organs. The authors say therapy translation has lagged. They urge biomarker-guided trials and microvascular repair.
Catalog record
| CREATOR | Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 149878 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |