Engineering an asymmetric cross-feeding consortium in Ogataea polymorpha driven by sulfur metabolism
Yuxia Fan, Xiaoxin Zhai, Yongjin J Zhou, Jiaoqi Gao · 2026
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Description
Fan and colleagues engineer a cross-feeding yeast partnership in Ogataea polymorpha. Their 2026 journal article uses sulfur metabolism to link two mutant strains. Each strain lacks one gene and cannot make a nutrient alone.
The team screened pairs of these auxotrophic mutants. Auxotrophs need a nutrient supplied from outside. The met10 and str3 pair grew back reliably together. Growth returned on both glucose and methanol. The dependency was asymmetric, meaning one-sided in part. The met10 strain could use many sulfur intermediates. The str3 strain relied only on homocysteine. Starting ratios shaped the final community. All cultures ended enriched for the met10 strain. The work guides stable synthetic yeast consortia.
Catalog record
| CREATOR | Yuxia Fan, Xiaoxin Zhai, Yongjin J Zhou, Jiaoqi Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28222 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |