Chemical‐Assembled Macrophage‐Engaging Glypican‐3 × Signal Regulatory Protein‐α (SIRP‐α) Bispecific Antibody for Immunotherapy Against Liver Cancer
Bo Tang, Wing Hei Leung, Chihao Shao, Dongfang Li, Kwai Man Lau, Macro K H Lui, Jingyi Liu, Jacky C H Chu, Clare S W Yan, Chi‐Ming Che, Xuechen Li, Wing‐Tak Wong, Larry Ming Cheung Chow, Terence K W Lee, Clarence T T Wong · 2026
Read Chemical‐Assembled Macrophage‐Engaging Glypican‐3 × Signal Regulatory Protein‐α (SIRP‐α) Bispecific Antibody for Immunotherapy Against Liver Cancer by Bo Tang, Wing Hei Leung, Chihao Shao, Dongfang Li, Kwai Man Lau, Macro K H Lui, Jingyi Liu, Jacky C H Chu, Clare S W Yan, Chi‐Ming Che, Xuechen Li, Wing‐Tak Wong, Larry Ming Cheung Chow, Terence K W Lee, Clarence T T Wong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13273848.txt.
Description
Tang and colleagues build a bispecific antibody against liver cancer using chemical assembly. Their 2026 journal article targets glypican-3, a marker on liver tumor cells. The antibody also blocks SIRP-alpha, a brake on immune cells called macrophages.
Standard bispecific antibodies need complex genetic production. This team used a rapid one-pot, two-step chemical process. Peptide dimers were linked to a native anti-SIRP-alpha antibody. The product draws macrophages toward tumor cells and boosts engulfing. In cell tests, tumor cell clearance beat the plain antibody. In mice, tumor growth fell by 68 percent. Macrophage entry into tumors rose, with more M1-type cells. Antigen presentation also increased. No visible body-wide toxicity appeared.
Catalog record
| CREATOR | Bo Tang, Wing Hei Leung, Chihao Shao, Dongfang Li, Kwai Man Lau, Macro K H Lui, Jingyi Liu, Jacky C H Chu, Clare S W Yan, Chi‐Ming Che, Xuechen Li, Wing‐Tak Wong, Larry Ming Cheung Chow, Terence K W Lee, Clarence T T Wong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53505 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |