Cold Agglutinin Disease–Like Genetic Signatures in Lymphoplasmacytic Lymphoma–Like Cases Challenge the WHO Fifth Edition Classification
Yuki Sato, Daisuke Koyama, Shoki Yamada, Kengo Suzuki, Masahiko Fukatsu, Yuka Oka, Yuko Hashimoto, Takayuki Ikezoe · 2026
Read Cold Agglutinin Disease–Like Genetic Signatures in Lymphoplasmacytic Lymphoma–Like Cases Challenge the WHO Fifth Edition Classification by Yuki Sato, Daisuke Koyama, Shoki Yamada, Kengo Suzuki, Masahiko Fukatsu, Yuka Oka, Yuko Hashimoto, Takayuki Ikezoe (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13273841.txt.
Description
Sato and colleagues examine eight lymphoma-like cases whose gene patterns resemble cold agglutinin disease. Their 2026 journal article questions how these cases fit the current WHO classification. Cold agglutinin disease is a rare blood disorder driven by antibodies.
All eight patients showed restricted use of one antibody gene, IGHV4-34. Their tumors carried changes in the KMT2D and CARD11 genes. Two common markers were absent. The MYD88 L265P change was not found. CXCR4 changes were also absent. This pattern differs from typical related lymphomas. The authors argue these cases form a distinct group. They suggest the classification should make room for them.
Catalog record
| CREATOR | Yuki Sato, Daisuke Koyama, Shoki Yamada, Kengo Suzuki, Masahiko Fukatsu, Yuka Oka, Yuko Hashimoto, Takayuki Ikezoe |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31612 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |