Anti-EGFR-based maintenance versus stop and go in patients with left-sided, non-MSI-H, RAS/BRAF-wt metastatic colorectal cancer: individual patient data pooled analysis☆
A. Raimondi, G. Tinè, V. Boige, A. De Stefano, A. Ballhausen, S. Gourgou, F. Giuliani, A. Stahler, G. Randon, M. Prisciandaro, P. Manca, M. Ambrosini, R. Fazio, S. Mohamed, G. Gronchi, G. Santabarbara, E. Brument, A.H.S. Alig, R. Miceli, O. Bouche, D.P. Modest, A. Avallone, F. Pietrantonio · 2026
Read Anti-EGFR-based maintenance versus stop and go in patients with left-sided, non-MSI-H, RAS/BRAF-wt metastatic colorectal cancer: individual patient data pooled analysis☆ by A. Raimondi, G. Tinè, V. Boige, A. De Stefano, A. Ballhausen, S. Gourgou, F. Giuliani, A. Stahler, G. Randon, M. Prisciandaro, P. Manca, M. Ambrosini, R. Fazio, S. Mohamed, G. Gronchi, G. Santabarbara, E. Brument, A.H.S. Alig, R. Miceli, O. Bouche, D.P. Modest, A. Avallone, F. Pietrantonio (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13273794.txt.
Description
Raimondi and colleagues pool patient-level data from four phase II trials in metastatic colorectal cancer. Their 2026 journal article covers left-sided tumors with normal RAS and BRAF genes. It compares two ways of using anti-EGFR antibody drugs.
One strategy gave the drug as steady maintenance. The other used stop-and-go dosing with planned breaks. The analysis included 378 patients. Overall survival did not differ significantly between strategies. Time without disease growth was shorter with stop-and-go. Yet time until the strategy failed was comparable. Anti-EGFR drugs block a growth signal on cancer cells. The authors say breaks may suit some patients. Survival was not harmed in this pooled group.
Catalog record
| CREATOR | A. Raimondi, G. Tinè, V. Boige, A. De Stefano, A. Ballhausen, S. Gourgou, F. Giuliani, A. Stahler, G. Randon, M. Prisciandaro, P. Manca, M. Ambrosini, R. Fazio, S. Mohamed, G. Gronchi, G. Santabarbara, E. Brument, A.H.S. Alig, R. Miceli, O. Bouche, D.P. Modest, A. Avallone, F. Pietrantonio |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37206 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |