The design of a small Bayesian hybrid-controlled trial utilizing time-to-event data from six published sources that used best alternative care to treat liver-predominant metastasis from primary ocular melanoma
David Zahrieh, Xiaofei Wang, Svetomir N Markovic, Vera J Suman · 2026
Read The design of a small Bayesian hybrid-controlled trial utilizing time-to-event data from six published sources that used best alternative care to treat liver-predominant metastasis from primary ocular melanoma by David Zahrieh, Xiaofei Wang, Svetomir N Markovic, Vera J Suman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13273716.txt.
Description
David Zahrieh and co-authors designed a small Bayesian trial for a rare eye cancer spread pattern in a 2026 paper. Ocular melanoma that spreads mainly to the liver leaves few patients for trials, so standard designs struggle to fill. Borrowing past control data can shrink the control arm without losing much power.
Their hybrid design draws progression free survival data from six published sources covering 309 patients treated with best alternative care. Simulations calibrated the design to keep sound error rates even when old and new data conflict. The Bayesian plan needed twenty-eight percent fewer participants than a traditional design with the same power to detect a halved hazard. The authors walk through the full design as a template for rare cancer trials.
Catalog record
| CREATOR | David Zahrieh, Xiaofei Wang, Svetomir N Markovic, Vera J Suman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |