Salidroside-loaded stem cell-derived artificial nanovesicles in hydrogel microneedles alleviate inflammation and enhance diabetic wound regeneration
Junhao Xia, Fengya Wang, Yang Song, Yu Xu, Mengru Zhu, Wenkun Sun, Yaqi Zhang, Sichun Wang, Qingwen Zhang, Keman He, Xin Guan, Hanhan Zhang, Xiulin Wang, Lukuan Liu, Jing Liu · 2026
Read Salidroside-loaded stem cell-derived artificial nanovesicles in hydrogel microneedles alleviate inflammation and enhance diabetic wound regeneration by Junhao Xia, Fengya Wang, Yang Song, Yu Xu, Mengru Zhu, Wenkun Sun, Yaqi Zhang, Sichun Wang, Qingwen Zhang, Keman He, Xin Guan, Hanhan Zhang, Xiulin Wang, Lukuan Liu, Jing Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13273594.txt.
Description
Junhao Xia and co-authors built a microneedle patch for diabetic wounds in a 2026 study. Diabetic wounds stall because inflammation persists, new vessels form poorly, and immune cells stay in attack mode. Their patch aims to reset that environment while delivering a healing compound through the skin.
The patch blends a gelatin based hydrogel with tiny vesicles made from stem cells and loaded with salidroside, a plant compound. In lab tests the system calmed inflammation and supported vessel growth. Deeper analyses showed it suppressed a key inflammatory pathway and nudged macrophages from attack mode toward repair mode. In animals, treated wounds closed much faster and released fewer inflammatory signals. The authors present the patch as a coordinated repair strategy.
Catalog record
| CREATOR | Junhao Xia, Fengya Wang, Yang Song, Yu Xu, Mengru Zhu, Wenkun Sun, Yaqi Zhang, Sichun Wang, Qingwen Zhang, Keman He, Xin Guan, Hanhan Zhang, Xiulin Wang, Lukuan Liu, Jing Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |