Sebetralstat for on-demand treatment of hereditary angioedema: A pooled analysis of placebo-controlled clinical trials☆
Emel Aygören-Pürsün, Danny M. Cohn, Nancy Agmon-Levin, Aleena Banerji, Jonathan A. Bernstein, Paula Busse, Mauro Cancian, Eunice Dias de Castro, Henriette Farkas, Vesna Grivcheva-Panovska, David Hagin, Roman Hakl, Daisuke Honda, Aharon Kessel, Tamar Kinaciyan, IFAAD, Marcin Kurowski, H. Henry Li, Ra · 2026
Read Sebetralstat for on-demand treatment of hereditary angioedema: A pooled analysis of placebo-controlled clinical trials☆ by Emel Aygören-Pürsün, Danny M. Cohn, Nancy Agmon-Levin, Aleena Banerji, Jonathan A. Bernstein, Paula Busse, Mauro Cancian, Eunice Dias de Castro, Henriette Farkas, Vesna Grivcheva-Panovska, David Hagin, Roman Hakl, Daisuke Honda, Aharon Kessel, Tamar Kinaciyan, IFAAD, Marcin Kurowski, H. Henry Li, Ra (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13273462.txt.
Description
Emel Aygören-Pürsün and a very large team pooled trial data on sebetralstat for hereditary angioedema attacks in a 2026 analysis. This inherited condition causes sudden swelling attacks, and sebetralstat is a pill that blocks a blood enzyme driving them. Two placebo controlled trials tested it as on-demand treatment.
The pooled set covered 377 treated attacks across two dose levels and placebo. Patients treated early, usually within about half an hour of attack onset. Both doses brought faster first relief than placebo, faster easing of severity, and more attacks fully resolved within a day. Most attacks were rated mild or moderate at the start. The analysis aims to give a fuller picture of benefit across the two trial designs.
Catalog record
| CREATOR | Emel Aygören-Pürsün, Danny M. Cohn, Nancy Agmon-Levin, Aleena Banerji, Jonathan A. Bernstein, Paula Busse, Mauro Cancian, Eunice Dias de Castro, Henriette Farkas, Vesna Grivcheva-Panovska, David Hagin, Roman Hakl, Daisuke Honda, Aharon Kessel, Tamar Kinaciyan, IFAAD, Marcin Kurowski, H. Henry Li, Ra |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |