Triple metachronous primary brain tumors: sequential occurrence of astrocytoma, atypical meningioma, and high-grade glioma without radiotherapy exposure. Illustrative case
Fei Wang, Mei Chang, Meng Yan, Youjia Qiu, Menghan Wang, Wanchun You, Juyi Zhang, Zhong Wang · 2026
Read Triple metachronous primary brain tumors: sequential occurrence of astrocytoma, atypical meningioma, and high-grade glioma without radiotherapy exposure. Illustrative case by Fei Wang, Mei Chang, Meng Yan, Youjia Qiu, Menghan Wang, Wanchun You, Juyi Zhang, Zhong Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13273439.txt.
Description
Fei Wang leads a 2026 illustrative case of three separate primary brain tumors arising in sequence in one woman, without any radiation exposure. At age 31 she had surgery for a low-grade astrocytoma in the left frontal lobe in 2000. Eighteen years later an atypical meningioma appeared at the same site, confirmed by tissue and marker tests.
Seven years after that, a high-grade glioma with oligodendroglioma-like features emerged. Molecular profiling showed distinct alterations in the meningioma and the glioma, supporting separate primary tumors despite a shared chromosome loss. The authors stress long-term vigilance and the value of full profiling to tell sequential tumors apart and guide care.
Catalog record
| CREATOR | Fei Wang, Mei Chang, Meng Yan, Youjia Qiu, Menghan Wang, Wanchun You, Juyi Zhang, Zhong Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22512 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |