Chloride at the spotlight—but not alone: towards a multi-ionic diuretic strategy
Marco Montomoli, Maria Ines Gil Martins Roxo, Miguel González-Rico, Julio Núñez, Gonzalo Núñez-Marín, Belén Aguilar Uriarte, Rafael De La Espriella, María Jesús Puchades, José L Górriz · 2026
Read Chloride at the spotlight—but not alone: towards a multi-ionic diuretic strategy by Marco Montomoli, Maria Ines Gil Martins Roxo, Miguel González-Rico, Julio Núñez, Gonzalo Núñez-Marín, Belén Aguilar Uriarte, Rafael De La Espriella, María Jesús Puchades, José L Górriz (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13273426.txt.
Description
Marco Montomoli and co-authors argue that chloride, not sodium alone, should guide water pill treatment in heart failure, in a paper from 2026. When water pills stop working well, doctors usually just raise the dose. The authors say that habit misses the root problem, which sits in a web of ions that move together in the kidney.
Low chloride often travels with low potassium and a blood shift toward alkaline, and that mix blunts the pills and worsens outcomes. The disturbed web drives the kidney to hold sodium and switches on hormone systems that add strain. A worked clinical case shows the authors' physiology guided plan in action. They propose checking and fixing the whole ion pattern rather than chasing sodium alone.
Catalog record
| CREATOR | Marco Montomoli, Maria Ines Gil Martins Roxo, Miguel González-Rico, Julio Núñez, Gonzalo Núñez-Marín, Belén Aguilar Uriarte, Rafael De La Espriella, María Jesús Puchades, José L Górriz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |