Acute toxicity assessment and metabolomic profiling of Taxus sumatrana leaf extract as a sustainable alternative to bark harvesting
Pamungkas Rizki Ferdian, Wanda Kuswanda, Hadi Sukardi Alikodra, Herjuno Ari Nugroho, Haidir, Ni Luh Putu Rischa Phadmacanty, Ardya Widyastuti, Rizki Rabeca Elfirta, Rini Madyastuti Purwono, Asep Hidayat, Yani Silfariani, Alif Zikri Fadhali · 2026
Read Acute toxicity assessment and metabolomic profiling of Taxus sumatrana leaf extract as a sustainable alternative to bark harvesting by Pamungkas Rizki Ferdian, Wanda Kuswanda, Hadi Sukardi Alikodra, Herjuno Ari Nugroho, Haidir, Ni Luh Putu Rischa Phadmacanty, Ardya Widyastuti, Rizki Rabeca Elfirta, Rini Madyastuti Purwono, Asep Hidayat, Yani Silfariani, Alif Zikri Fadhali (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13273224.txt.
Description
Pamungkas Rizki Ferdian and co-authors tested the safety of leaf extract from Taxus sumatrana in a 2026 study. This Indonesian tree yields anticancer compounds, but stripping its bark kills slow growing trees. Leaves regrow, so the team asked whether leaf extract is safe enough to use instead.
Mice given the extract by mouth showed no deaths within a day, even at the highest dose tested. Computer predictions for the one hundred compounds found in the leaves also pointed to low toxicity. Organ weights and blood chemistry barely shifted across dose groups. Liver and kidney changes under the microscope stayed minor. The authors support leaf use as a safer and more sustainable source, while calling for longer toxicity studies.
Catalog record
| CREATOR | Pamungkas Rizki Ferdian, Wanda Kuswanda, Hadi Sukardi Alikodra, Herjuno Ari Nugroho, Haidir, Ni Luh Putu Rischa Phadmacanty, Ardya Widyastuti, Rizki Rabeca Elfirta, Rini Madyastuti Purwono, Asep Hidayat, Yani Silfariani, Alif Zikri Fadhali |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |