Mitophagy-mediated immune evasion: Shared strategies of pathogens
Jun Li, Weijian Li, Dan Wang, Yulan Liu · 2026
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Description
Jun Li, Weijian Li, Dan Wang, and Yulan Liu reviewed how pathogens hide from immunity by exploiting mitophagy in a 2026 article. Mitophagy is the cell's way of clearing worn out mitochondria, its energy units. Some invaders turn this cleanup to their own advantage.
The review explains how mitophagy links with mitochondrial shape change, then surveys bacteria, viruses, and parasites that use it to blunt innate immune defenses. Several pathogens adjust mitophagy up or down at different infection stages to survive. The authors list four counter strategies, including drugs that tune the pathway and engineered mitochondria. Open questions include how timing shapes evasion and how shape change connects to cleanup. New imaging tools may help answer them.
Catalog record
| CREATOR | Jun Li, Weijian Li, Dan Wang, Yulan Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 145 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |