Efficacy of a transition to oral antimicrobial therapy for gram-negative bacilli bloodstream infection: systematic review and meta-analysis
Hitoshi Honda, Toshiki Miwa, David Warren, Akane Takamatsu · 2026
Read Efficacy of a transition to oral antimicrobial therapy for gram-negative bacilli bloodstream infection: systematic review and meta-analysis by Hitoshi Honda, Toshiki Miwa, David Warren, Akane Takamatsu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13273156.txt.
Description
Hitoshi Honda leads a 2026 systematic review and meta-analysis of switching from intravenous to oral antibiotics for bloodstream infections caused by gram-negative bacilli. Such infections carry high illness and cost. The team searched major databases from 1980 to March 2025 for trials and observational studies comparing the two routes.
Sixteen studies covered 4,858 patients switched to oral therapy and 4,961 kept on intravenous therapy. Pooled results for death and treatment failure showed no clear difference, with risk ratios of 0.95 and 1.11. Evidence quality was rated very low to moderate, and outcome definitions varied a lot. The authors say oral switching may be as effective, but high-quality trials are needed.
Catalog record
| CREATOR | Hitoshi Honda, Toshiki Miwa, David Warren, Akane Takamatsu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32161 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |