Salvianolic acid B alleviates depression-like behaviors by reducing neuronal injury and promoting neurogenesis in a manner associated with JAK-STAT signaling pathway inhibition
Ni Wang, Wei Guo, Xiaochen Yu, Yaqing Sun, Shujing Shi, Yan Xie · 2026
Read Salvianolic acid B alleviates depression-like behaviors by reducing neuronal injury and promoting neurogenesis in a manner associated with JAK-STAT signaling pathway inhibition by Ni Wang, Wei Guo, Xiaochen Yu, Yaqing Sun, Shujing Shi, Yan Xie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13273038.txt.
Description
Ni Wang and co-authors tested salvianolic acid B, a compound from a medicinal plant, against depression like behavior in a 2026 study. Depression involves brain inflammation, neuron damage, and poor growth of new neurons in the hippocampus. The team asked whether the compound protects the brain through one signaling pathway.
In lab cells injured by a stress hormone, the compound cut inflammation, oxidative stress, and cell death. In mice put through chronic mild stress, it improved behavior, calmed overactive immune cells in the brain, and reduced neuron death. New neuron growth and synaptic proteins also rose. The compound quieted the JAK-STAT pathway, and a drug that switches that pathway back on erased the benefit.
Catalog record
| CREATOR | Ni Wang, Wei Guo, Xiaochen Yu, Yaqing Sun, Shujing Shi, Yan Xie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |