Linking primary cilia defects to the “Big 3” neurodegenerative diseases — causal, consequential, or correlative?
Catherine Hong Huan Hor, Bor Luen Tang · 2026
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Description
Catherine Hong Huan Hor and Bor Luen Tang asked in a 2026 review whether faulty primary cilia help cause major brain diseases of aging. Primary cilia are tiny antenna like parts on cells that carry many signal receptors. Defects were long tied to early onset disorders, but links to later diseases have grown.
The review weighs evidence from models and patients with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. For each disease, the authors ask whether cilia faults drive harm, follow from it, or merely appear alongside it. Neuronal cilia host receptors for serotonin and other signals, so damage could matter deeply. The paper maps what is known and where proof is still thin.
Catalog record
| CREATOR | Catherine Hong Huan Hor, Bor Luen Tang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |