Systemic testosterone induces structural, immunological, and sex steroid receptor changes in human XX skin
Nina Dabrosin, Annelie Abrahamsson, Gunnar Kratz · 2026
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Description
Nina Dabrosin leads a 2026 study of how testosterone treatment changes skin in people with XX chromosomes who were assigned female at birth. Such treatment is part of gender-affirming care, and many patients later have surgery, so skin healing matters. The team analyzed discarded skin from plastic surgery, with and without testosterone treatment.
Treated skin showed a 2.77-fold rise in cells with androgen receptors in the dermis, the deeper skin layer, and almost three times the collagen density. Immune cells there fell by 43 percent. Changes in the outer layer included more fibronectin, a protein that helps tissue hold together. Overall, treated skin took on features resembling a male skin pattern.
Catalog record
| CREATOR | Nina Dabrosin, Annelie Abrahamsson, Gunnar Kratz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31325 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |