Resident microbes shape host immunity and protect against pathogen infection and inflammatory disease
Daichi Mori, Yoshiyuki Goto · 2026
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Description
Daichi Mori and Yoshiyuki Goto review how the microbes that live in the gut train the immune system and hold the line against invaders. These resident communities live in a stable partnership with the host. Their signals build the gut's barrier, teach its immune cells, and keep inflammation in check. The review follows the partnership cell by cell: gut lining cells, innate lymphoid cells, Th17 helper cells, and the B cells that pour out IgA antibodies.
Signals from the microbes guide each of those players as they develop and do their jobs. Together they form a defense that resists both true pathogens and opportunists while sparing the body's own tissue. When the partnership breaks, the same machinery can turn toward inflammatory disease. The authors frame health as a joint project of host and microbes.
Catalog record
| CREATOR | Daichi Mori, Yoshiyuki Goto |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |