Detection of MEN1 resistance mutations in cell-free DNA from acute leukemia patients treated with menin inhibitors
Neerav Shukla, Karmelina Charalambous, Shanita Li, Kaitlyn H. Ko, Hilary Casanova, Eric Buehler, Cassidy Cobbs, Ruchi Patel, Angela Rose Brannon, Mark D. Ewalt, Maria Luisa Sulis, William L. Carroll, Maria E. Arcila, Neeman Mohibullah, Michael Berger, Ross L. Levine, Eytan M. Stein, Ronak Shah, Sheng F. Cai · 2026
Read Detection of MEN1 resistance mutations in cell-free DNA from acute leukemia patients treated with menin inhibitors by Neerav Shukla, Karmelina Charalambous, Shanita Li, Kaitlyn H. Ko, Hilary Casanova, Eric Buehler, Cassidy Cobbs, Ruchi Patel, Angela Rose Brannon, Mark D. Ewalt, Maria Luisa Sulis, William L. Carroll, Maria E. Arcila, Neeman Mohibullah, Michael Berger, Ross L. Levine, Eytan M. Stein, Ronak Shah, Sheng F. Cai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13272672.txt.
Description
Neerav Shukla leads a 2026 letter on detecting drug resistance in acute leukemia from free DNA in blood plasma. Menin inhibitor drugs work for some leukemias, but changes in the MEN1 gene can stop them binding. Finding those changes now relies on bone marrow samples, which are invasive to take.
The team describes a sensitive sequencing assay, MSK-ACCESS MEN1, that looks for resistance changes in plasma free DNA. They compare its results with marrow sequencing in patients on menin inhibitors. Such blood testing would allow repeated checks with less burden, which matters in children who often need sedation for marrow sampling, and could flag resistance before relapse shows.
Catalog record
| CREATOR | Neerav Shukla, Karmelina Charalambous, Shanita Li, Kaitlyn H. Ko, Hilary Casanova, Eric Buehler, Cassidy Cobbs, Ruchi Patel, Angela Rose Brannon, Mark D. Ewalt, Maria Luisa Sulis, William L. Carroll, Maria E. Arcila, Neeman Mohibullah, Michael Berger, Ross L. Levine, Eytan M. Stein, Ronak Shah, Sheng F. Cai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13858 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |