Transcriptomic signatures of synaptic loss in Alzheimer’s disease
Lipeng Sun, Xinyuan Yang, Xiaomeng Xu, Lin Kang, Yingting Zheng, Qi Huang, Wei Xu, Yihui Guan, Yiwen Shen, Jun Liu, Yulei Deng, Shu Liu, Junfang Zhang, Fang Xie, Binyin Li · 2026
Read Transcriptomic signatures of synaptic loss in Alzheimer’s disease by Lipeng Sun, Xinyuan Yang, Xiaomeng Xu, Lin Kang, Yingting Zheng, Qi Huang, Wei Xu, Yihui Guan, Yiwen Shen, Jun Liu, Yulei Deng, Shu Liu, Junfang Zhang, Fang Xie, Binyin Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13272548.txt.
Description
Lipeng Sun and a large team of co-authors map gene patterns tied to synapse loss in Alzheimer's disease. Their 2026 study joins brain imaging with gene activity data. Synapse loss is a main driver of the memory and thinking decline in the disease. The team hunted for the gene programs that track that loss.
Scans measured synapse density in living patients from a tracked group. Matching gene data named over twelve hundred genes tied to synapse loss. The genes cluster around synapse upkeep, a disease protein's tagging, cell scaffolding, and protein disposal. Signal fell in two neuron types and rose in support and vessel cells. Repeat and follow-up scans backed the patterns, and protein data pointed at failing cell power plants.
Catalog record
| CREATOR | Lipeng Sun, Xinyuan Yang, Xiaomeng Xu, Lin Kang, Yingting Zheng, Qi Huang, Wei Xu, Yihui Guan, Yiwen Shen, Jun Liu, Yulei Deng, Shu Liu, Junfang Zhang, Fang Xie, Binyin Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |