Biotin-switch technique/proximity ligation assay-based method for in situ analysis of S-nitrosylated proteins
Mélina Meunier, Emma Levieux, Stéphanie Plenchette · 2026
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Description
Mélina Meunier, Emma Levieux, and Stéphanie Plenchette presented a new laboratory method in 2026 for finding modified proteins inside cells. Nitric oxide can attach to sulfur atoms in proteins, a change called S-nitrosylation that affects cell signals. Faulty levels of this change are linked to disease, yet spotting it in place is hard.
Their method, named SNO-Biotin-PLA, joins two known tools. The biotin switch technique tags the modified sites, and proximity ligation then reveals them where they sit in the cell. Earlier methods could detect or measure these proteins but not show a chosen one in its setting. The authors present the combined method as filling that gap for studies of nitric oxide signaling and disease.
Catalog record
| CREATOR | Mélina Meunier, Emma Levieux, Stéphanie Plenchette |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |