Titin modulation and left ventricular remodelling in chronic primary mitral regurgitation
Lobke L. Pype, Melissa Herwig, Sven L. Van Laer, Dina De Bock, Inez Rodrigus, Bernard P. Paelinck, Hanne M. Boen, Caroline M. Van De Heyning, Nazha Hamdani, Emeline M. Van Craenenbroeck · 2026
Read Titin modulation and left ventricular remodelling in chronic primary mitral regurgitation by Lobke L. Pype, Melissa Herwig, Sven L. Van Laer, Dina De Bock, Inez Rodrigus, Bernard P. Paelinck, Hanne M. Boen, Caroline M. Van De Heyning, Nazha Hamdani, Emeline M. Van Craenenbroeck (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13272440.txt.
Description
Lobke L Pype and coauthors examine in 2026 the giant spring protein titin in heart muscle of patients whose left ventricle enlarged out of proportion to a leaking mitral valve. Some valve prolapse patients remodel far beyond what the leak explains, hinting at a muscle disease of its own. Titin stiffness settings could be that hidden factor.
Biopsies from sixteen surgical patients were compared with six controls, alongside ultrasound and magnetic resonance imaging. The longer, softer titin form was upregulated in patients, raising its ratio to the stiff form. Chemical tagging of the stiff form differed between patients with normal and disproportionate remodeling, supporting a titin contribution.
Catalog record
| CREATOR | Lobke L. Pype, Melissa Herwig, Sven L. Van Laer, Dina De Bock, Inez Rodrigus, Bernard P. Paelinck, Hanne M. Boen, Caroline M. Van De Heyning, Nazha Hamdani, Emeline M. Van Craenenbroeck |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |