The metabolic-epigenetic landscape of aging: interplay between histone acetylation, lactylation, and glycation
Olena Bolgova, Inna Shypilova, Volodymyr Mavrych · 2026
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Description
Olena Bolgova and coauthors review in 2026 how three chemical marks on histone proteins, written by three different metabolic streams, jointly shape the aging genome. Acetylation follows mitochondrial fuel burning, lactylation follows sugar fermentation output, and glycation follows reactive carbonyl stress. Their crosstalk may explain much of epigenetic aging.
Falling NAD levels with age disable the sirtuin enzymes that erase acetyl marks, weakening repair and cleanup programs. Lactyl marks help during exercise and sleep yet harm when chronically high, driving brain inflammation in diabetes models. Glycation by methylglyoxal permanently displaces normal marks. The mini-review appraises controversies and open gaps.
Catalog record
| CREATOR | Olena Bolgova, Inna Shypilova, Volodymyr Mavrych |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |