The role of energy deficit in autophagy failure in Parkinson’s disease
Mihajlo Bosnjak, Maja Misirkic Marjanovic, Milica Kosic, Milos Mandic, Ljubica Vucicevic, Verica Paunovic, Ljubica Harhaji-Trajkovic · 2026
Read The role of energy deficit in autophagy failure in Parkinson’s disease by Mihajlo Bosnjak, Maja Misirkic Marjanovic, Milica Kosic, Milos Mandic, Ljubica Vucicevic, Verica Paunovic, Ljubica Harhaji-Trajkovic (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13272358.txt.
Description
Mihajlo Bosnjak and coauthors review in 2026 a paradox at the heart of Parkinson's disease: cells need energy to run their cleanup system, yet energy failure is a hallmark of the disease. The cleanup process, autophagy, normally rises under energy stress, but completing it consumes ATP, the cell's fuel. In Parkinson's, faulty mitochondria drain that fuel supply.
The authors propose a two-phase pattern where mild early energy loss stimulates cleanup while severe loss stalls it midway. Undigested cargo, including worn-out mitochondria, then piles up and deepens the energy crisis. This vicious cycle framing suggests treatment must restore energy, not just prod the cleanup machinery.
Catalog record
| CREATOR | Mihajlo Bosnjak, Maja Misirkic Marjanovic, Milica Kosic, Milos Mandic, Ljubica Vucicevic, Verica Paunovic, Ljubica Harhaji-Trajkovic |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |