The link between macrophage polarization and response to radiotherapy in cancers: mechanisms and therapeutic opportunities
Zibing Zhao, Zhuangzhuang Zheng · 2026
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Description
Zibing Zhao and Zhuangzhuang Zheng review in 2026 how macrophage states help decide whether radiotherapy succeeds against cancer. Macrophages flip between an attack-oriented state that aids tumor control and a suppressive state that shields tumors. Radiation itself can push that flip in either direction.
High-dose and particle radiation tend to favor the attack state, while standard fractionated treatment often breeds the suppressive one, feeding resistance. Oxygen shortage, metabolic signals, and cytokines in the tumor surroundings steer the balance. The authors survey strategies that block macrophage recruitment, remove suppressive cells, or reprogram them to restore radiation sensitivity.
Catalog record
| CREATOR | Zibing Zhao, Zhuangzhuang Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 135 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |