Effect of histology on the efficacy of first-line immune checkpoint inhibitors in advanced non-small cell lung cancer: a systematic review and network meta-analysis
Sihan Li, Tianyu He, Jun Chen, Tingting Liu, Xinyu Zhao, Jun Dang · 2026
Read Effect of histology on the efficacy of first-line immune checkpoint inhibitors in advanced non-small cell lung cancer: a systematic review and network meta-analysis by Sihan Li, Tianyu He, Jun Chen, Tingting Liu, Xinyu Zhao, Jun Dang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13272326.txt.
Description
Sihan Li and coauthors test in 2026 whether tumor tissue type changes how well first-line immune checkpoint drugs work in advanced lung cancer. These drugs are now standard first treatment, yet squamous and non-squamous tumors may respond differently to particular regimens. A network method can rank many drug combinations never compared directly.
The analysis pooled 41 phase three trials with 23,871 patients and 31 drug regimens. Rankings differed sharply by tissue type; one chemo-immunotherapy pair topped the non-squamous list while placing differently in squamous disease. The authors advise matching regimen choice to histology rather than treating lung cancer as one uniform group.
Catalog record
| CREATOR | Sihan Li, Tianyu He, Jun Chen, Tingting Liu, Xinyu Zhao, Jun Dang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |