Spatial transcriptomics in Alzheimer's disease: technologies, challenges and discoveries
Christina Huan Shi, Juan C Piña-Crespo, Kevin Y Yip, Timothy Y Huang · 2026
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Description
Christina Huan Shi is lead author of a 2026 review on spatial transcriptomics in Alzheimer's disease, a brain disorder of ageing marked by amyloid plaques and tau tangles. Spatial transcriptomics maps which genes are active at each spot in a tissue slice, letting researchers see how cells near plaques and tangles change, in both mouse models and human brain.
The review covers current platforms, the analysis pipelines that handle their data, and what studies using them have found in Alzheimer's disease. It also weighs the limits and practical challenges of each platform. Combined with single-cell methods and imaging, the authors argue, spatial approaches promise major strides in Alzheimer's and related disorders.
Catalog record
| CREATOR | Christina Huan Shi, Juan C Piña-Crespo, Kevin Y Yip, Timothy Y Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90636 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |