Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer’s disease
Lindsay A. Welikovitch, Derek H. Oakley, Rachel E. Bennett, Alberto Serrano-Pozo, Haoyang Zhu, Nancy E. Ruiz-Uribe, Theodore J. Zwang, Lori B. Chibnik, Teresa Gomez-Isla, Matthew P. Frosch, Donald S. Marks, Stephen Salloway, Charles Bernick, David Greeley, Caitlin S. Latimer, Amber Nolan, R. Matthew Hutchison, Carrie E. Rubel, Thierry Bussiere, Edward D. Plowey, C. Dirk Keene, Bradley T. Hyman · 2026
Read Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer’s disease by Lindsay A. Welikovitch, Derek H. Oakley, Rachel E. Bennett, Alberto Serrano-Pozo, Haoyang Zhu, Nancy E. Ruiz-Uribe, Theodore J. Zwang, Lori B. Chibnik, Teresa Gomez-Isla, Matthew P. Frosch, Donald S. Marks, Stephen Salloway, Charles Bernick, David Greeley, Caitlin S. Latimer, Amber Nolan, R. Matthew Hutchison, Carrie E. Rubel, Thierry Bussiere, Edward D. Plowey, C. Dirk Keene, Bradley T. Hyman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13272220.txt.
Description
Lindsay A. Welikovitch is lead author of a 2026 neuropathological study, an examination of brain tissue after death, of aducanumab, an antibody drug against amyloid beta, in Alzheimer's disease trial participants. Scans and fluid tests already showed such antibodies clear amyloid from the brain; this study checked the tissue itself.
The team compared a key memory region from six treated participants, who died between seven weeks and five years after their last dose, with nine matched untreated patients. Treated brains showed a strong reduction in amyloid burden, with some amyloid redistributed around small vessels. A tau-related measure near plaques fell, but established tangles did not change, and immune cell reactivity matched untreated patients. Plaques appeared to rebuild with time since the last dose.
Catalog record
| CREATOR | Lindsay A. Welikovitch, Derek H. Oakley, Rachel E. Bennett, Alberto Serrano-Pozo, Haoyang Zhu, Nancy E. Ruiz-Uribe, Theodore J. Zwang, Lori B. Chibnik, Teresa Gomez-Isla, Matthew P. Frosch, Donald S. Marks, Stephen Salloway, Charles Bernick, David Greeley, Caitlin S. Latimer, Amber Nolan, R. Matthew Hutchison, Carrie E. Rubel, Thierry Bussiere, Edward D. Plowey, C. Dirk Keene, Bradley T. Hyman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49376 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |