LncRNA NORAD Promotes Spinal Cord Injury via miR-22-3p/PTEN Axis to Regulate Oxidative Stress and Inflammation in Neuronal Cells
Chenming Zhang, Lin Chen, Yue Pan, Shiwei Yu, Qingyi Wang, Yongfu Chen, Haitao Xu, Yuanyuan Zhang · 2026
Read LncRNA NORAD Promotes Spinal Cord Injury via miR-22-3p/PTEN Axis to Regulate Oxidative Stress and Inflammation in Neuronal Cells by Chenming Zhang, Lin Chen, Yue Pan, Shiwei Yu, Qingyi Wang, Yongfu Chen, Haitao Xu, Yuanyuan Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13272196.txt.
Description
Chenming Zhang is lead author of a 2026 journal article on a long non-coding RNA called NORAD in spinal cord injury, severe trauma to the central nervous system. Such RNAs do not build proteins but regulate other genes, and the team explored whether NORAD drives oxidative stress and inflammation in nerve cells after injury.
The study enrolled 100 spinal cord injury patients and 80 healthy controls, plus rat and cell models. NORAD levels were high in patients and predicted the disease well. Blocking NORAD in rats improved hind-leg movement recovery and eased oxidative stress, cell damage, and nerve inflammation. Cell tests traced the chain: NORAD suppresses a small RNA, miR-22-3p, which normally restrains the gene PTEN, and rescue experiments confirmed the linked pathway.
Catalog record
| CREATOR | Chenming Zhang, Lin Chen, Yue Pan, Shiwei Yu, Qingyi Wang, Yongfu Chen, Haitao Xu, Yuanyuan Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35502 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |