Research progress on multispecies animal models of chronic rhinosinusitis: modeling strategies and research applications
Minghao Li, Dongdong Zhu, Cuida Meng · 2026
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Description
Minghao Li and coauthors review in 2026 animal models of chronic rhinosinusitis across several species and how to choose among them. This long-lasting sinus inflammation burdens quality of life, and treatment progress lags behind the disease's immune complexity. Mice dominate the lab, yet their sinuses differ greatly from human ones.
Sheep drain their sinuses in ways closer to humans, while pigs mirror stubborn tissue remodeling in severe disease. The review judges each model against human disease types, from allergy-driven type 2 inflammation to other forms. A decision framework steers researchers toward the model that fits their question rather than the most convenient one.
Catalog record
| CREATOR | Minghao Li, Dongdong Zhu, Cuida Meng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |