Co-expression of MARCKS and GSDMD pathway genes in tuberculous meningitis: a multi-omics analysis of blood-brain barrier disruption
Mengyu Luan, Xiaoyou Chen, Yu Lu · 2026
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Description
Mengyu Luan and coauthors analyze in 2026 gene activity in tuberculous meningitis, the deadliest form of tuberculosis, where damage to the blood-brain barrier drives much of the harm. A protein called MARCKS, which helps organize the cell skeleton, appeared alongside the cell-bursting GSDMD pathway. The study blends several omics datasets with lab validation.
Three genes stood out as raised in patients, with MARCKS concentrated in microglia in a mouse model and also raised in patients' blood cells. Its levels moved together with key members of the inflammatory cell-death pathway. The authors position MARCKS as a hub linking inflammation and barrier breakdown, pending checks in human brain tissue.
Catalog record
| CREATOR | Mengyu Luan, Xiaoyou Chen, Yu Lu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |