Molecular and microenvironmental drivers of malignant transformation from oral potentially malignant disorders to oral squamous cell carcinoma
Vasundra V., Shajitha R., Sundaresan S., Magesh R. · 2026
Read Molecular and microenvironmental drivers of malignant transformation from oral potentially malignant disorders to oral squamous cell carcinoma by Vasundra V., Shajitha R., Sundaresan S., Magesh R. (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13272074.txt.
Description
Vasundra V and coauthors review in 2026 how pre-cancerous mouth lesions turn into oral squamous cell carcinoma. These lesions carry widely varying risk, and grading tissue under the microscope predicts that risk poorly. A clearer molecular picture could help doctors watch the right patients closely.
The review traces gene instability, chemical gene switches, chronic inflammation, and changes in surrounding tissue as joint drivers. Several growth signaling pathways recur across studies, feeding cell flexibility and immune escape. One condition, oral submucous fibrosis, is treated as a high-risk model where stiffened tissue itself pushes cells toward cancer. The authors call for marker-based risk assessment.
Catalog record
| CREATOR | Vasundra V., Shajitha R., Sundaresan S., Magesh R. |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 119 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |