Neural stem cell-derived extracellular vesicles drive early neuroprotective and anti-apoptotic responses in spinal cord injury organotypic slices
Kristyna Sintakova, Vojtech Sprincl, Ivan Arzhanov, Ruslan Klassen, Lukas Valihrach, Nataliya Romanyuk · 2026
Read Neural stem cell-derived extracellular vesicles drive early neuroprotective and anti-apoptotic responses in spinal cord injury organotypic slices by Kristyna Sintakova, Vojtech Sprincl, Ivan Arzhanov, Ruslan Klassen, Lukas Valihrach, Nataliya Romanyuk (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13272055.txt.
Description
Kristyna Sintakova and coauthors test in 2026 whether tiny parcels released by neural stem cells can protect injured spinal cord tissue in the lab. Spinal cord injury leaves lasting damage, and stem cell benefits seem to travel largely through these parcels, called small extracellular vesicles. Two human stem cell sources supplied the vesicles for testing.
Rat spinal cord slices were injured and treated at once, then examined after three days. Injury raised cell-death markers and broke down structural proteins, while vesicle treatment pulled those measures back toward normal. Both cell sources protected the tissue, shifting survival signaling in a favorable direction.
Catalog record
| CREATOR | Kristyna Sintakova, Vojtech Sprincl, Ivan Arzhanov, Ruslan Klassen, Lukas Valihrach, Nataliya Romanyuk |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |