Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits
Thomas H. Julian, Haoran Dou, Jinming Duan, Jinghan Huang, Esther Yoo, David J. Green, Andrew Strange, Elham Alhathli, Matthew Sperrin, Pearse A. Keane, Emily Y. Chew, Bernard Keavney, Tomas W. Fitzgerald, Johnathan Cooper-Knock, Ewan Birney, Alejandro F. Frangi, Panagiotis I. Sergouniotis · 2026
Read Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits by Thomas H. Julian, Haoran Dou, Jinming Duan, Jinghan Huang, Esther Yoo, David J. Green, Andrew Strange, Elham Alhathli, Matthew Sperrin, Pearse A. Keane, Emily Y. Chew, Bernard Keavney, Tomas W. Fitzgerald, Johnathan Cooper-Knock, Ewan Birney, Alejandro F. Frangi, Panagiotis I. Sergouniotis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13271892.txt.
Description
Thomas H. Julian is lead author of a 2026 multi-omic analysis linking eye imaging to cardiovascular and neurological traits. The eye allows direct, noninvasive viewing of blood vessels and nerve tissue. That makes it a recognised source of markers for heart and brain disease risk. This study used UK Biobank data to map how broad those links are.
The team trained artificial intelligence models to compress retinal scans and eye photographs into 256-number summaries. Those summaries associated with diseases including ischaemic heart disease, stroke-related disease, Parkinson's disease, and dementia. Cross-checking other data layers linked the eye features to heart and brain anatomy, fat metabolism, and gene sets tied to neurodegeneration. The authors frame the eye as a composite indicator of whole-body health.
Catalog record
| CREATOR | Thomas H. Julian, Haoran Dou, Jinming Duan, Jinghan Huang, Esther Yoo, David J. Green, Andrew Strange, Elham Alhathli, Matthew Sperrin, Pearse A. Keane, Emily Y. Chew, Bernard Keavney, Tomas W. Fitzgerald, Johnathan Cooper-Knock, Ewan Birney, Alejandro F. Frangi, Panagiotis I. Sergouniotis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73391 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |