Rationale for the Use of 8‐Aminoguanine for the Management of Cystitis
Lori A Birder, Joel N H Stern, Robert Moldwin, Edwin K Jackson · 2026
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Description
Lori Birder, Joel Stern, Robert Moldwin, and Edwin Jackson review a candidate drug for bladder pain. Their 2026 paper deals with cystitis, which brings bladder pain and urgent, frequent urination. Two forms are covered: a pain syndrome with no clear cause, and a form tied to infection or cancer treatment. Good drug targets for the pain remain scarce.
The candidate, 8-aminoguanine, blocks an enzyme that turns protective purines into damaging ones. Patients with the pain syndrome show skewed purine levels that match that path. In rats with drug-induced cystitis, the oral drug prevented all seen harm, from tissue damage to raised urination. The authors argue it could cut pain and guard the bladder in patients.
Catalog record
| CREATOR | Lori A Birder, Joel N H Stern, Robert Moldwin, Edwin K Jackson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |